Vitamin B12

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Vitamin B12

Vitamin B12 is cobalamin, and cyanocobalamin is a man-made form thereof.[1] It's biological half-life is ~6 days (400 days in the liver)[2]

The active form of Vitamin B12 is methylcobalamin, or "methyl B12". [Source needed]

Methylcobalamin has the following advantages:[3]

  • It is the natural form of cobalamin
  • Does not require conversion, within the body, to the methyl form
  • Does not produce cyanide within the body

See also

http://www.paulgolding.id.au/B12_AND_FOLATE/Pages/B12AndFolateInformation/B12Notes/Treatment/OralB12Supplements.html

To review following studies;

  • Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve. Folia Pharmacol Japon 1976;72(2):259-68. [Japanese]
  • Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122(2):140-3.
  • Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 1998;21(12):1775-8.

Storage

  • Methylcobalamin is light sensitive[4]
  • Methylcobalamin may be temperature sensitive[5]

References

  1. Cyanocobalamin,WebMD,http://www.webmd.com/drugs/2/drug-1010/cyanocobalamin-vitamin-b-12-oral/details
  2. Vitam B12,Google,https://www.google.com/search?q=vitamin+b12
  3. Oral B12 Supplements,Paul Golding,http://www.paulgolding.id.au/B12_AND_FOLATE/Pages/B12AndFolateInformation/B12Notes/Treatment/OralB12Supplements.html
  4. Methylcobalamin,Wikipedia,https://en.wikipedia.org/wiki/Methylcobalamin#/media/File:B12_methylcobalamin.jpg
  5. Methylcobalamin,Wikipedia,https://en.wikipedia.org/wiki/Methylcobalamin#/media/File:B12_methylcobalamin.jpg