Oxidative Stress

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Oxidative stress theory for adult onset of psychosis:

Oxidative stresses gradually increase until GSH (Glutathione) and MT (Metallothionein) proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT (neurotransmitter) levels, and disruption of the blood brain barrier. As in Wilson’s Disease, sudden onset of a mental illness in young adulthood may result.[1]

Define: psychosis: a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.[2]

All major phenotypes of schizophrenia involve severe oxidative stress, [and] oxidative overload depletes GSH and reduces glutamate activity at NMDA receptors.[1]

Abnormal methylation and severe oxidative stress are major causes of epigenetic errors, [and] greater than 95% of schizophrenics exhibit abnormal methylation or oxidative overload.[1]

Define: schizophrenia: a long-term mental disorder of a type involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, unfitting actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.[3]


  • Must watch movie; "Time to Choose", it highlights many of the possible reasons for why worldwide health is declining. It is available internationally on Vimeo OnDemand https://vimeo.com/ondemand/timetochoose - if one cannot purchase due to cost, even the trailer will give an initial idea.


  1. 1.0 1.1 1.2 Biochemical imbalances in mental health populations, William J. Walsh PhD, Walsh Institute, http://www.walshinstitute.org/uploads/1/7/9/9/17997321/biochemical_imbalances_in_mental_health_populations.pdf
  2. define: psychosis, Google, https://www.google.com/search?q=define%3Apsychosis
  3. define: schizophrenia, Google, https://www.google.com/search?q=define%3Aschizophrenia (edited)