Difference between revisions of "D-Serine"
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'''D-Serine''' is an <u>obligatory endogenous coagonist</u> of the N-methyl-D-aspartate receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine (GLY) modulatory site (GMS).<ref>''D-Serine in Neuropsychiatric Disorders: New Advances'',Hindawi,https://www.hindawi.com/archive/2014/859735/</ref> | '''D-Serine''' is an <u>obligatory endogenous coagonist</u> of the N-methyl-D-aspartate receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine (GLY) modulatory site (GMS).<ref>''D-Serine in Neuropsychiatric Disorders: New Advances'',Hindawi,https://www.hindawi.com/archive/2014/859735/</ref> | ||
| − | + | Definition: co-agonist: (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.<ref>co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist</ref> | |
| − | + | Definition: agonist: (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.<ref>agonist,wiktionary,https://en.wiktionary.org/wiki/agonist</ref> | |
Revision as of 19:53, 7 April 2017
General info
The NMDA (N-methyl-D-aspartate) receptor (also known as NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane.[1]
D-Serine supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced NMDA signaling, which includes cocaine dependence and schizophrenia.[2]
D-Serine is an obligatory endogenous coagonist of the N-methyl-D-aspartate receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine (GLY) modulatory site (GMS).[3]
Definition: co-agonist: (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.[4] Definition: agonist: (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.[5]
Other interesting links
OCD, Glycine - https://www.hindawi.com/archive/2014/859735/
References
- ↑ NMDA Receptor, Wikipedia, https://en.wikipedia.org/wiki/NMDA_receptor
- ↑ D-Serine', Examine, https://examine.com/supplements/d-serine/
- ↑ D-Serine in Neuropsychiatric Disorders: New Advances,Hindawi,https://www.hindawi.com/archive/2014/859735/
- ↑ co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist
- ↑ agonist,wiktionary,https://en.wiktionary.org/wiki/agonist
