D-Serine
NMDA and D-Serine
The NMDA (N-methyl-D-aspartate) receptor (also known as NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane.[1]
D-Serine supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced NMDA signaling, which includes cocaine dependence and schizophrenia.[2]
D-Serine is an obligatory endogenous coagonist of the N-methyl-D-aspartate receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine (GLY) modulatory site (GMS).[3]
Define: co-agonist: (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.[4]
Define: agonist: (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.[5]
Oxidative Stress
Oxidative stress theory for adult onset of psychosis:
Oxidative stresses gradually increase until GSH and MT proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT levels, and disruption of the blood brain barrier. As in Wilson’s Disease, sudden onset of a mental illness in young adulthood may result.[6]
Define: psychosis: a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.[7]
Other interesting links
OCD, Glycine - https://www.hindawi.com/archive/2014/859735/
References
- ↑ NMDA Receptor, Wikipedia, https://en.wikipedia.org/wiki/NMDA_receptor
- ↑ D-Serine', Examine, https://examine.com/supplements/d-serine/
- ↑ D-Serine in Neuropsychiatric Disorders: New Advances,Hindawi,https://www.hindawi.com/archive/2014/859735/
- ↑ co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist
- ↑ agonist,wiktionary,https://en.wiktionary.org/wiki/agonist
- ↑ Biochemical imbalances in mental health populations, William J. Walsh PhD, Walsh Institute, http://www.walshinstitute.org/uploads/1/7/9/9/17997321/biochemical_imbalances_in_mental_health_populations.pdf
- ↑ define: psychosis, Google, https://www.google.com/search?q=define%3Apsychosis
