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2020-02-17T03:25:59Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."''''' -- Jesus<br />
<br />
Welcome to Practical Healing!<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, UR Krypto, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Laverty Pathology charged about $144 for the Pyrrole test in 2020, Douglas HM Pathology charged about $138.50 in 2017. Please check updated prices. <br />
**** Be careful with using a Douglas HM Pathology form at Laverty Pathology as you may be charged a much higher premium for some tests like Cu/Zn/Caeruloplasmin/VitD<br />
***** Instead, ask your doctor to prescribe on a Laverty Pathology form, using their Laverty's Integrative Health Profiles. <br />
** Copper (Cu), Zinc (zn), Caeruloplasmin, Histamine (Whole Blood Histamine), Vit D<br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this, including myself<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[Taurine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=772
Main Page
2020-02-17T03:25:45Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."''''' -- Jesus<br />
<br />
Welcome to Practical Healing!<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, UR Krypto, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Laverty Pathology charged about $144 for the Pyrrole test in 2020, Douglas HM Pathology charged about $138.50 in 2017. Please check updated prices. <br />
**** Be careful with using a Douglas HM Pathology form at Laverty Pathology as you may be charged a much higher premium for some tests like Cu/Zn/Caeruloplasmin/VitD.<br />
***** Instead, ask your doctor to prescribe on a Laverty Pathology form, using their Laverty's Integrative Health Profiles. <br />
** Copper (Cu), Zinc (zn), Caeruloplasmin, Histamine (Whole Blood Histamine), Vit D<br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this, including myself.<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[Taurine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=771
Main Page
2020-02-17T03:24:36Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."''''' -- Jesus<br />
<br />
Welcome to Practical Healing!<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, UR Krypto, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Laverty Pathology charged about $144 for the Pyrrole test in 2020, Douglas HM Pathology charged about $138.50 in 2017. Please check updated prices. <br />
**** Be careful with using a Douglas HM Pathology form at Laverty Pathology as you may be charged a much higher premium for some tests like Cu/Zn/Caeruloplasmin/VitD.<br />
***** Instead, ask your doctor to prescribe on a Laverty Pathology form, using their Laverty's Integrative Health Profiles. <br />
** Copper (Cu), Zinc (zn), Caeruloplasmin, Histamine (Whole Blood Histamine), Vit D<br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[Taurine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Cardiovascular&diff=770
Cardiovascular
2017-10-02T21:26:32Z
<p>Roel Van de Paar: /* Baby Aspirin */</p>
<hr />
<div>== Baby Aspirin ==<br />
* Pro; May help prevent heart attack<br />
* Con; May cause [TBD]<br />
<br />
* Dr. Pfeiffer advises against baby aspirin due to possible gastrointestinal side effects? (find source)<br />
* Dr. Stephen Sinatra advises it only against secondary heart attack prevention <ref>https://www.drsinatra.com/is-aspirin-therapy-right-for-you</ref><br />
** Dr. Sinatra also advises to test whether Aspirin is effective or not, see https://www.aspirinworks.com/<br />
** Dr. Sinatra also mentions gastrointestinal side effects<br />
* Regular low dose aspirin therapy may also be recommended for certain people who have atrial fibrillation (a heart rhythm disorder) to prevent stroke – a known complication of atrial fibrillation. Current Australian guidelines do not recommend the use of daily low-dose aspirin to prevent cardiovascular disease in people with no past history, including those thought to be at high risk.<ref>Aspirin, MyDr, http://www.mydr.com.au/medicines/aspirin</ref><br />
<br />
== See Also ==<br />
* [[Taurine]]<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Cardiovascular&diff=769
Cardiovascular
2017-10-02T21:26:22Z
<p>Roel Van de Paar: /* Baby Aspirin */</p>
<hr />
<div>== Baby Aspirin ==<br />
* Pro; May help prevent heart attack<br />
* Con; May cause<br />
<br />
* Dr. Pfeiffer advises against baby aspirin due to possible gastrointestinal side effects? (find source)<br />
* Dr. Stephen Sinatra advises it only against secondary heart attack prevention <ref>https://www.drsinatra.com/is-aspirin-therapy-right-for-you</ref><br />
** Dr. Sinatra also advises to test whether Aspirin is effective or not, see https://www.aspirinworks.com/<br />
** Dr. Sinatra also mentions gastrointestinal side effects<br />
* Regular low dose aspirin therapy may also be recommended for certain people who have atrial fibrillation (a heart rhythm disorder) to prevent stroke – a known complication of atrial fibrillation. Current Australian guidelines do not recommend the use of daily low-dose aspirin to prevent cardiovascular disease in people with no past history, including those thought to be at high risk.<ref>Aspirin, MyDr, http://www.mydr.com.au/medicines/aspirin</ref><br />
<br />
== See Also ==<br />
* [[Taurine]]<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Cardiovascular&diff=768
Cardiovascular
2017-10-02T21:26:11Z
<p>Roel Van de Paar: </p>
<hr />
<div>== Baby Aspirin ==<br />
Pro; May help prevent heart attack<br />
Con; May cause<br />
<br />
* Dr. Pfeiffer advises against baby aspirin due to possible gastrointestinal side effects? (find source)<br />
* Dr. Stephen Sinatra advises it only against secondary heart attack prevention <ref>https://www.drsinatra.com/is-aspirin-therapy-right-for-you</ref><br />
** Dr. Sinatra also advises to test whether Aspirin is effective or not, see https://www.aspirinworks.com/<br />
** Dr. Sinatra also mentions gastrointestinal side effects<br />
* Regular low dose aspirin therapy may also be recommended for certain people who have atrial fibrillation (a heart rhythm disorder) to prevent stroke – a known complication of atrial fibrillation. Current Australian guidelines do not recommend the use of daily low-dose aspirin to prevent cardiovascular disease in people with no past history, including those thought to be at high risk.<ref>Aspirin, MyDr, http://www.mydr.com.au/medicines/aspirin</ref><br />
<br />
== See Also ==<br />
* [[Taurine]]<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=767
Main Page
2017-10-02T21:25:45Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."''''' -- Jesus<br />
<br />
Welcome to Practical Healing!<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Doing the test via Laverty Pathology (charge should be $95 as per their national pricing; $75 for the lab test + $20 for the handling) is much cheaper then using Douglas HM Pathology which charges $138.50 per test<br />
** Full copper tests <info to add><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[Taurine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Taurine&diff=766
Taurine
2017-10-02T21:25:28Z
<p>Roel Van de Paar: </p>
<hr />
<div>== Taurine ==<br />
* Taurine is a conditionally-essential<ref name=taurexam>Taurine,Examine.com,https://examine.com/supplements/taurine/</ref> organic acid derived from the amino acid cysteine. if sufficient cysteine is available, it can be synthesised in the pancreas<ref name="taur1">Ten Benefits of Taurine,Poliquin GroupTM Editorial Staff,http://main.poliquingroup.com/ArticlesMultimedia/Articles/Article/782/Ten_Benefits_of_Taurine.aspx</ref>.<br />
* Taurine calms the nervous system - behaving more like a neurotransmitter<ref name="taur1"></ref>.<br />
* Vegetarians and Vegans can be deficient in Taurine<ref name="taur1"></ref>.<br />
* Lack of Taurine leads to to chronic anxiety<ref name="taur1"></ref>.<br />
* Taurine is highly effective antioxidant. Use in conjunction with Omega-3 seems recommended <ref name="taur1"></ref>.<br />
* Improves mood and sleep. Taurine raises GABA<ref name="taur1"></ref>.<br />
<br />
== Taurine: Heart Health ==<br />
* May be able to reduce/eliminate atrial fibrillation<ref name="afibbers">Episode Reduction/Elimination Protocols,Afibbers.org,http://www.afibbers.org/resources/eliminationprotocols.pdf</ref>.<br />
* Combine with Magnesium and Fish<ref name="taur1"></ref>.<br />
* Lowers blood pressure <ref name="taur1"></ref>.<br />
<br />
== Questions ==<br />
* It is known that athletes/resistance trainees will deplete this nutrient<ref name="taur1"></ref>. Would excessive sweating cause the same?<br />
* Derived from Cysteine. What is the interaction/effect of combination with N-Acetyl L-Cysteine (NAC)?<br />
* Some people may have issues producing Taurine<ref name="taur1"></ref>? "...this assumes an error in inborn metabolism impairing one's ability to synthesis taurine. The average human would not need to worry about outright taurine deficiency and its clinical manifestations." <ref name=taurexam></ref> <br />
<br />
== To Research ==<br />
* Carnitine: essential for fat burning and works synergistic ally with Taurine. Taurine is required in the initial phase of fat metabolism, and carnitine takes fat into the cell [for use?].<ref name="taur1"></ref>.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Taurine&diff=765
Taurine
2017-10-02T21:24:50Z
<p>Roel Van de Paar: /* Taurine: Heart Health */</p>
<hr />
<div>== Taurine ==<br />
* Taurine is a conditionally-essential<ref name=taurexam>Taurine,Examine.com,https://examine.com/supplements/taurine/</ref> organic acid derived from the amino acid cysteine. if sufficient cysteine is available, it can be synthesised in the pancreas<ref name="taur1">Ten Benefits of Taurine,Poliquin GroupTM Editorial Staff,http://main.poliquingroup.com/ArticlesMultimedia/Articles/Article/782/Ten_Benefits_of_Taurine.aspx</ref>.<br />
* Taurine calms the nervous system - behaving more like a neurotransmitter<ref name="taur1"></ref>.<br />
* Vegetarians and Vegans can be deficient in Taurine<ref name="taur1"></ref>.<br />
* Lack of Taurine leads to to chronic anxiety<ref name="taur1"></ref>.<br />
* Taurine is highly effective antioxidant. Use in conjunction with Omega-3 seems recommended <ref name="taur1"></ref>.<br />
* Improves mood and sleep. Taurine raises GABA<ref name="taur1"></ref>.<br />
<br />
== Taurine: Heart Health ==<br />
* May be able to reduce/eliminate atrial fibrillation<ref name="afibbers">Episode Reduction/Elimination Protocols,Afibbers.org,http://www.afibbers.org/resources/eliminationprotocols.pdf</ref>.<br />
* Combine with Magnesium and Fish<ref name="taur1"></ref>.<br />
* Lowers blood pressure <ref name="taur1"></ref>.<br />
<br />
== Questions ==<br />
* It is known that athletes/resistance trainees will deplete this nutrient<ref name="taur1"></ref>. Would excessive sweating cause the same?<br />
* Derived from Cysteine. What is the interaction/effect of combination with N-Acetyl L-Cysteine (NAC)?<br />
* Some people may have issues producing Taurine<ref name="taur1"></ref>? "...this assumes an error in inborn metabolism impairing one's ability to synthesis taurine. The average human would not need to worry about outright taurine deficiency and its clinical manifestations." <ref name=taurexam></ref> <br />
<br />
== Research ==<br />
* Carnitine: essential for fat burning and works synergistic ally with Taurine. Taurine is required in the initial phase of fat metabolism, and carnitine takes fat into the cell [for use?].<ref name="taur1"></ref>.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Taurine&diff=764
Taurine
2017-10-02T21:24:39Z
<p>Roel Van de Paar: /* Taurine: Heart Health */</p>
<hr />
<div>== Taurine ==<br />
* Taurine is a conditionally-essential<ref name=taurexam>Taurine,Examine.com,https://examine.com/supplements/taurine/</ref> organic acid derived from the amino acid cysteine. if sufficient cysteine is available, it can be synthesised in the pancreas<ref name="taur1">Ten Benefits of Taurine,Poliquin GroupTM Editorial Staff,http://main.poliquingroup.com/ArticlesMultimedia/Articles/Article/782/Ten_Benefits_of_Taurine.aspx</ref>.<br />
* Taurine calms the nervous system - behaving more like a neurotransmitter<ref name="taur1"></ref>.<br />
* Vegetarians and Vegans can be deficient in Taurine<ref name="taur1"></ref>.<br />
* Lack of Taurine leads to to chronic anxiety<ref name="taur1"></ref>.<br />
* Taurine is highly effective antioxidant. Use in conjunction with Omega-3 seems recommended <ref name="taur1"></ref>.<br />
* Improves mood and sleep. Taurine raises GABA<ref name="taur1"></ref>.<br />
<br />
== Taurine: Heart Health ==<br />
* May be able to reduce/eliminate atrial fibrillation<ref name="afibbers">Episode Reduction/Elimination Protocols,Afibbers.org,http://www.afibbers.org/resources/eliminationprotocols.pdf</ref><br />
* Combine with Magnesium and Fish<ref name="taur1"></ref>.<br />
* Lowers blood pressure <ref name="taur1"></ref>.<br />
<br />
== Questions ==<br />
* It is known that athletes/resistance trainees will deplete this nutrient<ref name="taur1"></ref>. Would excessive sweating cause the same?<br />
* Derived from Cysteine. What is the interaction/effect of combination with N-Acetyl L-Cysteine (NAC)?<br />
* Some people may have issues producing Taurine<ref name="taur1"></ref>? "...this assumes an error in inborn metabolism impairing one's ability to synthesis taurine. The average human would not need to worry about outright taurine deficiency and its clinical manifestations." <ref name=taurexam></ref> <br />
<br />
== Research ==<br />
* Carnitine: essential for fat burning and works synergistic ally with Taurine. Taurine is required in the initial phase of fat metabolism, and carnitine takes fat into the cell [for use?].<ref name="taur1"></ref>.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Taurine&diff=763
Taurine
2017-10-02T21:23:01Z
<p>Roel Van de Paar: Created page with "== Taurine == * Taurine is a conditionally-essential<ref name=taurexam>Taurine,Examine.com,https://examine.com/supplements/taurine/</ref> organic acid derived from the amino a..."</p>
<hr />
<div>== Taurine ==<br />
* Taurine is a conditionally-essential<ref name=taurexam>Taurine,Examine.com,https://examine.com/supplements/taurine/</ref> organic acid derived from the amino acid cysteine. if sufficient cysteine is available, it can be synthesised in the pancreas<ref name="taur1">Ten Benefits of Taurine,Poliquin GroupTM Editorial Staff,http://main.poliquingroup.com/ArticlesMultimedia/Articles/Article/782/Ten_Benefits_of_Taurine.aspx</ref>.<br />
* Taurine calms the nervous system - behaving more like a neurotransmitter<ref name="taur1"></ref>.<br />
* Vegetarians and Vegans can be deficient in Taurine<ref name="taur1"></ref>.<br />
* Lack of Taurine leads to to chronic anxiety<ref name="taur1"></ref>.<br />
* Taurine is highly effective antioxidant. Use in conjunction with Omega-3 seems recommended <ref name="taur1"></ref>.<br />
* Improves mood and sleep. Taurine raises GABA<ref name="taur1"></ref>.<br />
<br />
== Taurine: Heart Health ==<br />
* Combine with Magnesium and Fish<ref name="taur1"></ref>.<br />
* Lowers blood pressure <ref name="taur1"></ref>.<br />
<br />
== Questions ==<br />
* It is known that athletes/resistance trainees will deplete this nutrient<ref name="taur1"></ref>. Would excessive sweating cause the same?<br />
* Derived from Cysteine. What is the interaction/effect of combination with N-Acetyl L-Cysteine (NAC)?<br />
* Some people may have issues producing Taurine<ref name="taur1"></ref>? "...this assumes an error in inborn metabolism impairing one's ability to synthesis taurine. The average human would not need to worry about outright taurine deficiency and its clinical manifestations." <ref name=taurexam></ref> <br />
<br />
== Research ==<br />
* Carnitine: essential for fat burning and works synergistic ally with Taurine. Taurine is required in the initial phase of fat metabolism, and carnitine takes fat into the cell [for use?].<ref name="taur1"></ref>.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=156
Main Page
2017-07-14T20:52:51Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."''''' -- Jesus<br />
<br />
Welcome to Practical Healing!<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Doing the test via Laverty Pathology (charge should be $95 as per their national pricing; $75 for the lab test + $20 for the handling) is much cheaper then using Douglas HM Pathology which charges $138.50 per test<br />
** Full copper tests <info to add><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=155
Main Page
2017-07-14T20:52:39Z
<p>Roel Van de Paar: </p>
<hr />
<div>''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."'' -- Jesus<br />
<br />
Welcome to Practical Healing!<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Doing the test via Laverty Pathology (charge should be $95 as per their national pricing; $75 for the lab test + $20 for the handling) is much cheaper then using Douglas HM Pathology which charges $138.50 per test<br />
** Full copper tests <info to add><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=154
Main Page
2017-07-14T20:52:26Z
<p>Roel Van de Paar: </p>
<hr />
<div>''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."'' -- Jesus<br />
<br />
'''Welcome to Practical Healing!'''<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Doing the test via Laverty Pathology (charge should be $95 as per their national pricing; $75 for the lab test + $20 for the handling) is much cheaper then using Douglas HM Pathology which charges $138.50 per test<br />
** Full copper tests <info to add><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=153
Main Page
2017-07-14T20:51:23Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."''' -- Jesus<br />
<br />
'''Welcome to Practical Healing!'''<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Doing the test via Laverty Pathology (charge should be $95 as per their national pricing; $75 for the lab test + $20 for the handling) is much cheaper then using Douglas HM Pathology which charges $138.50 per test<br />
** Full copper tests <info to add><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=152
Main Page
2017-07-14T20:50:46Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''Welcome to Practical Healing!'''<br />
<br />
''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."'' -- Jesus<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Doing the test via Laverty Pathology (charge should be $95 as per their national pricing; $75 for the lab test + $20 for the handling) is much cheaper then using Douglas HM Pathology which charges $138.50 per test<br />
** Full copper tests <info to add><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Oxidative_Stress&diff=151
Oxidative Stress
2017-07-13T01:28:13Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''Oxidative stress theory for adult onset of psychosis:'''<br />
<br />
Oxidative stresses gradually increase until GSH (Glutathione) and MT (Metallothionein) proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT (neurotransmitter) levels, and disruption of the blood brain barrier. As in Wilson’s Disease, sudden onset of a mental illness in young adulthood may result.<ref name=walsh_imbalances>Biochemical imbalances in mental health populations, William J. Walsh PhD, Walsh Institute, http://www.walshinstitute.org/uploads/1/7/9/9/17997321/biochemical_imbalances_in_mental_health_populations.pdf</ref><br />
<br />
''Define: psychosis:'' a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.<ref>define: psychosis, Google, https://www.google.com/search?q=define%3Apsychosis</ref><br />
<br />
All major phenotypes of schizophrenia involve severe oxidative stress, [and] oxidative overload depletes GSH and reduces glutamate activity at NMDA receptors.<ref name="walsh_imbalances" /><br />
<br />
Abnormal methylation and severe oxidative stress are major causes of epigenetic errors, [and] greater than 95% of schizophrenics exhibit abnormal methylation or oxidative overload.<ref name="walsh_imbalances" /><br />
<br />
''Define: schizophrenia:'' a long-term mental disorder of a type involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, unfitting actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.<ref>define: schizophrenia, Google, https://www.google.com/search?q=define%3Aschizophrenia (edited)</ref><br />
<br />
'''Resources'''<br />
* Must watch movie; "Time to Choose", it highlights many of the possible reasons for why worldwide health is declining. It is available internationally on Vimeo OnDemand https://vimeo.com/ondemand/timetochoose - if one cannot purchase due to cost, even the trailer will give an initial idea.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=150
Main Page
2017-07-13T01:24:20Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''Welcome to Practical Healing!'''<br />
<br />
''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."'' -- Jesus<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Doing the test via Laverty Pathology (charge should be $95 exactly; $75 for the lab test + $20 for the handling) is much cheaper then using Douglas HM Pathology which charges $138.50 per test<br />
** Full copper tests <info to add><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=149
Main Page
2017-07-13T01:23:43Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''Welcome to Practical Healing!'''<br />
<br />
''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."'' -- Jesus<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
**** Doing the test via Laverty Pathology (charge should be $95 exactly, $75 for the lab test + $20 for the handling) is much cheaper then using Douglas HM Pathology which charges $138.50 per test<br />
** Full copper tests <info to add><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Talk:Main_Page&diff=146
Talk:Main Page
2017-06-27T04:21:21Z
<p>Roel Van de Paar: Created page with "* External links should open in a new page and be nofollow"</p>
<hr />
<div>* External links should open in a new page and be nofollow</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=D-Serine&diff=145
D-Serine
2017-06-27T04:20:50Z
<p>Roel Van de Paar: </p>
<hr />
<div>== D-Serine and NMDA Receptors ==<br />
<br />
The NMDA (N-methyl-D-aspartate) receptor (also known as NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when '''glutamate''' and '''glycine (or D-serine)''' bind to it, and when activated it allows positively charged ions to flow through the cell membrane.<ref>''NMDA Receptor'', Wikipedia, https://en.wikipedia.org/wiki/NMDA_receptor</ref><br />
<br />
'''D-Serine''' supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced NMDA signaling, which includes cocaine dependence and schizophrenia.<ref>''D-Serine', Examine, https://examine.com/supplements/d-serine/</ref><br />
<br />
Treatment with '''D-serine''' can improve performance in tasks related to recognition learning and working memory, suggesting that this agent can be useful for the treatment of disorders involving declines in these cognitive domains. <ref>Effects of low-dose D-serine on recognition and working memory in mice,https://www.ncbi.nlm.nih.gov/pubmed/21556803</ref><br />
<br />
Because a <u>structural abnormality</u> and <u>NMDA receptor hypofunction</u> has been demonstrated in the cortex and hippocampus of schizophrenic subjects, D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<ref>Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat,https://www.ncbi.nlm.nih.gov/pubmed/15249164</ref><br />
<br />
''Define: hypofunction:'' Reduced, low, or inadequate function.<ref>Farlex Partner Medical Dictionary,© Farlex 2012</ref><br />
<br />
'''D-Serine''', synthesized in the brain by serine racemase from '''L-serine''' (its enantiomer), serves as a neuromodulator by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site of the NMDA-type glutamate receptor (NMDAR). For the receptor to open, glutamate and either glycine or D-serine must bind to it; in addition a pore blocker must not be bound (e.g. Mg2+ or Pb2+).[11] In fact, D-serine is a more potent agonist at the glycine site on the NMDAR than glycine itself.<ref>Serine,Wikipedia,https://en.wikipedia.org/wiki/Serine</ref><br />
<br />
''Define: agonist:'' (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.<ref>agonist,wiktionary,https://en.wiktionary.org/wiki/agonist</ref><br />
<br />
'''D-Serine''' is an <u>obligatory endogenous coagonist</u> of the NMDA receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine modulatory site.<ref>''D-Serine in Neuropsychiatric Disorders: New Advances'',Hindawi,https://www.hindawi.com/archive/2014/859735/</ref><br />
<br />
''Define: endogenous:'' (biology) growing or originating from within an organism.<ref>Define: endogenous,Google,https://www.google.com/search?q=define%3Aendogenous</ref><br /><br />
''Define: co-agonist:'' (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.<ref>co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist</ref><br /><br />
<br />
In addition to alleviating several diseases and conditions, '''D-serine''' may have its dark side in neurodegenerative disease.<ref name="D-Serine_other_side">D-serine as a gliotransmitter and its roles in brain development and disease,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632749/</ref> D-serine may play a role in excitotoxic neuronal death in Alzheimer’s disease and also in amyotrophic lateral sclerosis (ALS) as a principal cause for motoneuron death (considered to be excitotoxicity).<ref name="D-Serine_other_side"></ref> The presence of endogenous D-serine has been shown to be necessary for most, if not all, NMDAR-mediated excitotoxicity observed in rat brain slices and in vivo.<ref name="D-Serine_other_side"></ref> Pretreatment of rat hippocampal organotypic slices with D-serine deaminase was shown to practically abolish NMDA-mediated excitotoxicity, suggesting that D-serine, rather than glycine, participates in these excitotoxic events in the hippocampus.<ref name="D-Serine_other_side"></ref><br />
<br />
It is conceivable that '''D-serine''' signalling could be involved in brain disorders in which NMDARs contributes to the pathophysiology, such as stroke. Here, an indirect reduction of NMDAR-mediated excitotoxicity through modified D-serine supply may in principle suggest new therapeutic avenues. It is encouraging in that respect that SR deletion (i.e. serine racemase (SR), which converts L-serine to D-serine) was recently reported to reduce tissue damage in a mouse stroke model (Mustafa et al., 2010). However, increasing D-serine levels might on the other hand help to overcome cognitive impairments related to the dysfunction of NMDAR signaling. Promising early studies showed that '''Dcycloserine''', a partial agonist at the NMDAR co-agonist site, can improve spatial learning in rats (Monahan et al., 1989). Therapeutic approaches targeting D-serine signaling will therefore have to strike the balance between preventing NMDAR-dependent damage and avoiding cognitive impairment.<ref>D-Serine: A key to synaptic plasticity?,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375648/pdf/ukmss-48553.pdf</ref><br />
<br />
''Define: excitotoxicity:'' Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.<ref>Excitotoxicity,wikipedia,https://en.wikipedia.org/wiki/Excitotoxicity</ref><br />
<br />
== Other interesting links ==<br />
* Schizophrenia, symptoms - https://www.sane.org/mental-health-and-illness/facts-and-guides/schizophrenia<br /><br />
* OCD, Glycine - https://www.hindawi.com/archive/2014/859735/<br /><br />
* [[Oxidative Stress]]<br />
* Oxidation & it's results - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964749/#R37<br />
<br />
== '''Hypothesis''' ==<br />
* Increasing D-serine levels may help to overcome cognitive impairments related to the dysfunction of NMDAR signaling.<br />
* Increasing D-serine levels may cause NMDAR-dependent damage.<br />
* D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=D-Serine&diff=144
D-Serine
2017-06-27T04:20:36Z
<p>Roel Van de Paar: </p>
<hr />
<div>== D-Serine and NMDA Receptors ==<br />
<br />
The NMDA (N-methyl-D-aspartate) receptor (also known as NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when '''glutamate''' and '''glycine (or D-serine)''' bind to it, and when activated it allows positively charged ions to flow through the cell membrane.<ref>''NMDA Receptor'', Wikipedia, https://en.wikipedia.org/wiki/NMDA_receptor</ref><br />
<br />
'''D-Serine''' supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced NMDA signaling, which includes cocaine dependence and schizophrenia.<ref>''D-Serine', Examine, https://examine.com/supplements/d-serine/</ref><br />
<br />
Treatment with '''D-serine''' can improve performance in tasks related to recognition learning and working memory, suggesting that this agent can be useful for the treatment of disorders involving declines in these cognitive domains. <ref>Effects of low-dose D-serine on recognition and working memory in mice,https://www.ncbi.nlm.nih.gov/pubmed/21556803</ref><br />
<br />
Because a <u>structural abnormality</u> and <u>NMDA receptor hypofunction</u> has been demonstrated in the cortex and hippocampus of schizophrenic subjects, D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<ref>Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat,https://www.ncbi.nlm.nih.gov/pubmed/15249164</ref><br />
<br />
''Define: hypofunction:'' Reduced, low, or inadequate function.<ref>Farlex Partner Medical Dictionary,© Farlex 2012</ref><br />
<br />
'''D-Serine''', synthesized in the brain by serine racemase from '''L-serine''' (its enantiomer), serves as a neuromodulator by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site of the NMDA-type glutamate receptor (NMDAR). For the receptor to open, glutamate and either glycine or D-serine must bind to it; in addition a pore blocker must not be bound (e.g. Mg2+ or Pb2+).[11] In fact, D-serine is a more potent agonist at the glycine site on the NMDAR than glycine itself.<ref>Serine,Wikipedia,https://en.wikipedia.org/wiki/Serine</ref><br />
<br />
''Define: agonist:'' (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.<ref>agonist,wiktionary,https://en.wiktionary.org/wiki/agonist</ref><br />
<br />
'''D-Serine''' is an <u>obligatory endogenous coagonist</u> of the NMDA receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine modulatory site.<ref>''D-Serine in Neuropsychiatric Disorders: New Advances'',Hindawi,https://www.hindawi.com/archive/2014/859735/</ref><br />
<br />
''Define: endogenous:'' (biology) growing or originating from within an organism.<ref>Define: endogenous,Google,https://www.google.com/search?q=define%3Aendogenous</ref><br /><br />
''Define: co-agonist:'' (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.<ref>co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist</ref><br /><br />
<br />
In addition to alleviating several diseases and conditions, '''D-serine''' may have its dark side in neurodegenerative disease.<ref name="D-Serine_other_side">D-serine as a gliotransmitter and its roles in brain development and disease,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632749/</ref> D-serine may play a role in excitotoxic neuronal death in Alzheimer’s disease and also in amyotrophic lateral sclerosis (ALS) as a principal cause for motoneuron death (considered to be excitotoxicity).<ref name="D-Serine_other_side"></ref> The presence of endogenous D-serine has been shown to be necessary for most, if not all, NMDAR-mediated excitotoxicity observed in rat brain slices and in vivo.<ref name="D-Serine_other_side"></ref> Pretreatment of rat hippocampal organotypic slices with D-serine deaminase was shown to practically abolish NMDA-mediated excitotoxicity, suggesting that D-serine, rather than glycine, participates in these excitotoxic events in the hippocampus.<ref name="D-Serine_other_side"></ref><br />
<br />
It is conceivable that '''D-serine''' signalling could be involved in brain disorders in which NMDARs contributes to the pathophysiology, such as stroke. Here, an indirect reduction of NMDAR-mediated excitotoxicity through modified D-serine supply may in principle suggest new therapeutic avenues. It is encouraging in that respect that SR deletion (i.e. serine racemase (SR), which converts L-serine to D-serine) was recently reported to reduce tissue damage in a mouse stroke model (Mustafa et al., 2010). However, increasing D-serine levels might on the other hand help to overcome cognitive impairments related to the dysfunction of NMDAR signaling. Promising early studies showed that '''Dcycloserine''', a partial agonist at the NMDAR co-agonist site, can improve spatial learning in rats (Monahan et al., 1989). Therapeutic approaches targeting D-serine signaling will therefore have to strike the balance between preventing NMDAR-dependent damage and avoiding cognitive impairment.<ref>D-Serine: A key to synaptic plasticity?,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375648/pdf/ukmss-48553.pdf</ref><br />
<br />
''Define: excitotoxicity:'' Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.<ref>Excitotoxicity,wikipedia,https://en.wikipedia.org/wiki/Excitotoxicity</ref><br />
<br />
== Other interesting links ==<br />
* [[Oxidative Stress]]<br />
* Schizophrenia, symptoms - https://www.sane.org/mental-health-and-illness/facts-and-guides/schizophrenia<br /><br />
* OCD, Glycine - https://www.hindawi.com/archive/2014/859735/<br /><br />
* Oxidation & it's results - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964749/#R37<br />
<br />
== '''Hypothesis''' ==<br />
* Increasing D-serine levels may help to overcome cognitive impairments related to the dysfunction of NMDAR signaling.<br />
* Increasing D-serine levels may cause NMDAR-dependent damage.<br />
* D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=143
Main Page
2017-06-27T04:20:05Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''Welcome to Practical Healing!'''<br />
<br />
''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."'' -- Jesus<br />
<br />
How are you feeling today?<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Read the following books: (while these books have 'Brain' in the title, they reference many other areas of health also)<br />
** "Nutrient Power: Heal Your Biochemistry and Heal Your Brain" by William J. Walsh <br />
** "Why Isn't My Brain Working?" by Dr. Datis Kharrazian <br />
* Get blood and urine tests done as prescribed by your GP (found in first step above). Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
** Full copper tests <info to add><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
* [[Oxidative Stress]]<br />
<br />
Draft supplement pages;<br />
* [[Vitamin C]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (also includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
* [[D-Serine]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Oxidative_Stress&diff=142
Oxidative Stress
2017-06-27T04:19:30Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''Oxidative stress theory for adult onset of psychosis:'''<br />
<br />
Oxidative stresses gradually increase until GSH (Glutathione) and MT (Metallothionein) proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT (neurotransmitter) levels, and disruption of the blood brain barrier. As in Wilson’s Disease, sudden onset of a mental illness in young adulthood may result.<ref name=walsh_imbalances>Biochemical imbalances in mental health populations, William J. Walsh PhD, Walsh Institute, http://www.walshinstitute.org/uploads/1/7/9/9/17997321/biochemical_imbalances_in_mental_health_populations.pdf</ref><br />
<br />
''Define: psychosis:'' a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.<ref>define: psychosis, Google, https://www.google.com/search?q=define%3Apsychosis</ref><br />
<br />
All major phenotypes of schizophrenia involve severe oxidative stress, [and] oxidative overload depletes GSH and reduces glutamate activity at NMDA receptors.<ref name="walsh_imbalances" /><br />
<br />
Abnormal methylation and severe oxidative stress are major causes of epigenetic errors, [and] greater than 95% of schizophrenics exhibit abnormal methylation or oxidative overload.<ref name="walsh_imbalances" /><br />
<br />
''Define: schizophrenia:'' a long-term mental disorder of a type involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, unfitting actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.<ref>define: schizophrenia, Google, https://www.google.com/search?q=define%3Aschizophrenia (edited)</ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Oxidative_Stress&diff=141
Oxidative Stress
2017-06-27T04:19:20Z
<p>Roel Van de Paar: Created page with "== Oxidative Stress == '''Oxidative stress theory for adult onset of psychosis:''' Oxidative stresses gradually increase until GSH (Glutathione) and MT (Metallothionein) pro..."</p>
<hr />
<div>== Oxidative Stress ==<br />
<br />
'''Oxidative stress theory for adult onset of psychosis:'''<br />
<br />
Oxidative stresses gradually increase until GSH (Glutathione) and MT (Metallothionein) proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT (neurotransmitter) levels, and disruption of the blood brain barrier. As in Wilson’s Disease, sudden onset of a mental illness in young adulthood may result.<ref name=walsh_imbalances>Biochemical imbalances in mental health populations, William J. Walsh PhD, Walsh Institute, http://www.walshinstitute.org/uploads/1/7/9/9/17997321/biochemical_imbalances_in_mental_health_populations.pdf</ref><br />
<br />
''Define: psychosis:'' a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.<ref>define: psychosis, Google, https://www.google.com/search?q=define%3Apsychosis</ref><br />
<br />
All major phenotypes of schizophrenia involve severe oxidative stress, [and] oxidative overload depletes GSH and reduces glutamate activity at NMDA receptors.<ref name="walsh_imbalances" /><br />
<br />
Abnormal methylation and severe oxidative stress are major causes of epigenetic errors, [and] greater than 95% of schizophrenics exhibit abnormal methylation or oxidative overload.<ref name="walsh_imbalances" /><br />
<br />
''Define: schizophrenia:'' a long-term mental disorder of a type involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, unfitting actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.<ref>define: schizophrenia, Google, https://www.google.com/search?q=define%3Aschizophrenia (edited)</ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=D-Serine&diff=140
D-Serine
2017-06-27T04:19:14Z
<p>Roel Van de Paar: </p>
<hr />
<div>== D-Serine and NMDA Receptors ==<br />
<br />
The NMDA (N-methyl-D-aspartate) receptor (also known as NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when '''glutamate''' and '''glycine (or D-serine)''' bind to it, and when activated it allows positively charged ions to flow through the cell membrane.<ref>''NMDA Receptor'', Wikipedia, https://en.wikipedia.org/wiki/NMDA_receptor</ref><br />
<br />
'''D-Serine''' supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced NMDA signaling, which includes cocaine dependence and schizophrenia.<ref>''D-Serine', Examine, https://examine.com/supplements/d-serine/</ref><br />
<br />
Treatment with '''D-serine''' can improve performance in tasks related to recognition learning and working memory, suggesting that this agent can be useful for the treatment of disorders involving declines in these cognitive domains. <ref>Effects of low-dose D-serine on recognition and working memory in mice,https://www.ncbi.nlm.nih.gov/pubmed/21556803</ref><br />
<br />
Because a <u>structural abnormality</u> and <u>NMDA receptor hypofunction</u> has been demonstrated in the cortex and hippocampus of schizophrenic subjects, D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<ref>Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat,https://www.ncbi.nlm.nih.gov/pubmed/15249164</ref><br />
<br />
''Define: hypofunction:'' Reduced, low, or inadequate function.<ref>Farlex Partner Medical Dictionary,© Farlex 2012</ref><br />
<br />
'''D-Serine''', synthesized in the brain by serine racemase from '''L-serine''' (its enantiomer), serves as a neuromodulator by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site of the NMDA-type glutamate receptor (NMDAR). For the receptor to open, glutamate and either glycine or D-serine must bind to it; in addition a pore blocker must not be bound (e.g. Mg2+ or Pb2+).[11] In fact, D-serine is a more potent agonist at the glycine site on the NMDAR than glycine itself.<ref>Serine,Wikipedia,https://en.wikipedia.org/wiki/Serine</ref><br />
<br />
''Define: agonist:'' (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.<ref>agonist,wiktionary,https://en.wiktionary.org/wiki/agonist</ref><br />
<br />
'''D-Serine''' is an <u>obligatory endogenous coagonist</u> of the NMDA receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine modulatory site.<ref>''D-Serine in Neuropsychiatric Disorders: New Advances'',Hindawi,https://www.hindawi.com/archive/2014/859735/</ref><br />
<br />
''Define: endogenous:'' (biology) growing or originating from within an organism.<ref>Define: endogenous,Google,https://www.google.com/search?q=define%3Aendogenous</ref><br /><br />
''Define: co-agonist:'' (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.<ref>co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist</ref><br /><br />
<br />
In addition to alleviating several diseases and conditions, '''D-serine''' may have its dark side in neurodegenerative disease.<ref name="D-Serine_other_side">D-serine as a gliotransmitter and its roles in brain development and disease,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632749/</ref> D-serine may play a role in excitotoxic neuronal death in Alzheimer’s disease and also in amyotrophic lateral sclerosis (ALS) as a principal cause for motoneuron death (considered to be excitotoxicity).<ref name="D-Serine_other_side"></ref> The presence of endogenous D-serine has been shown to be necessary for most, if not all, NMDAR-mediated excitotoxicity observed in rat brain slices and in vivo.<ref name="D-Serine_other_side"></ref> Pretreatment of rat hippocampal organotypic slices with D-serine deaminase was shown to practically abolish NMDA-mediated excitotoxicity, suggesting that D-serine, rather than glycine, participates in these excitotoxic events in the hippocampus.<ref name="D-Serine_other_side"></ref><br />
<br />
It is conceivable that '''D-serine''' signalling could be involved in brain disorders in which NMDARs contributes to the pathophysiology, such as stroke. Here, an indirect reduction of NMDAR-mediated excitotoxicity through modified D-serine supply may in principle suggest new therapeutic avenues. It is encouraging in that respect that SR deletion (i.e. serine racemase (SR), which converts L-serine to D-serine) was recently reported to reduce tissue damage in a mouse stroke model (Mustafa et al., 2010). However, increasing D-serine levels might on the other hand help to overcome cognitive impairments related to the dysfunction of NMDAR signaling. Promising early studies showed that '''Dcycloserine''', a partial agonist at the NMDAR co-agonist site, can improve spatial learning in rats (Monahan et al., 1989). Therapeutic approaches targeting D-serine signaling will therefore have to strike the balance between preventing NMDAR-dependent damage and avoiding cognitive impairment.<ref>D-Serine: A key to synaptic plasticity?,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375648/pdf/ukmss-48553.pdf</ref><br />
<br />
''Define: excitotoxicity:'' Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.<ref>Excitotoxicity,wikipedia,https://en.wikipedia.org/wiki/Excitotoxicity</ref><br />
<br />
== Other interesting links ==<br />
Schizophrenia, symptoms - https://www.sane.org/mental-health-and-illness/facts-and-guides/schizophrenia<br /><br />
OCD, Glycine - https://www.hindawi.com/archive/2014/859735/<br /><br />
Oxidation & it's results - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964749/#R37<br />
<br />
== '''Hypothesis''' ==<br />
* Increasing D-serine levels may help to overcome cognitive impairments related to the dysfunction of NMDAR signaling.<br />
* Increasing D-serine levels may cause NMDAR-dependent damage.<br />
* D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=D-Serine&diff=135
D-Serine
2017-04-28T05:54:22Z
<p>Roel Van de Paar: /* Other interesting links */</p>
<hr />
<div>== D-Serine and NMDA Receptors ==<br />
<br />
The NMDA (N-methyl-D-aspartate) receptor (also known as NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when '''glutamate''' and '''glycine (or D-serine)''' bind to it, and when activated it allows positively charged ions to flow through the cell membrane.<ref>''NMDA Receptor'', Wikipedia, https://en.wikipedia.org/wiki/NMDA_receptor</ref><br />
<br />
'''D-Serine''' supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced NMDA signaling, which includes cocaine dependence and schizophrenia.<ref>''D-Serine', Examine, https://examine.com/supplements/d-serine/</ref><br />
<br />
Treatment with '''D-serine''' can improve performance in tasks related to recognition learning and working memory, suggesting that this agent can be useful for the treatment of disorders involving declines in these cognitive domains. <ref>Effects of low-dose D-serine on recognition and working memory in mice,https://www.ncbi.nlm.nih.gov/pubmed/21556803</ref><br />
<br />
Because a <u>structural abnormality</u> and <u>NMDA receptor hypofunction</u> has been demonstrated in the cortex and hippocampus of schizophrenic subjects, D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<ref>Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat,https://www.ncbi.nlm.nih.gov/pubmed/15249164</ref><br />
<br />
''Define: hypofunction:'' Reduced, low, or inadequate function.<ref>Farlex Partner Medical Dictionary,© Farlex 2012</ref><br />
<br />
'''D-Serine''', synthesized in the brain by serine racemase from '''L-serine''' (its enantiomer), serves as a neuromodulator by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site of the NMDA-type glutamate receptor (NMDAR). For the receptor to open, glutamate and either glycine or D-serine must bind to it; in addition a pore blocker must not be bound (e.g. Mg2+ or Pb2+).[11] In fact, D-serine is a more potent agonist at the glycine site on the NMDAR than glycine itself.<ref>Serine,Wikipedia,https://en.wikipedia.org/wiki/Serine</ref><br />
<br />
''Define: agonist:'' (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.<ref>agonist,wiktionary,https://en.wiktionary.org/wiki/agonist</ref><br />
<br />
'''D-Serine''' is an <u>obligatory endogenous coagonist</u> of the NMDA receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine modulatory site.<ref>''D-Serine in Neuropsychiatric Disorders: New Advances'',Hindawi,https://www.hindawi.com/archive/2014/859735/</ref><br />
<br />
''Define: endogenous:'' (biology) growing or originating from within an organism.<ref>Define: endogenous,Google,https://www.google.com/search?q=define%3Aendogenous</ref><br /><br />
''Define: co-agonist:'' (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.<ref>co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist</ref><br /><br />
<br />
In addition to alleviating several diseases and conditions, '''D-serine''' may have its dark side in neurodegenerative disease.<ref name="D-Serine_other_side">D-serine as a gliotransmitter and its roles in brain development and disease,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632749/</ref> D-serine may play a role in excitotoxic neuronal death in Alzheimer’s disease and also in amyotrophic lateral sclerosis (ALS) as a principal cause for motoneuron death (considered to be excitotoxicity).<ref name="D-Serine_other_side"></ref> The presence of endogenous D-serine has been shown to be necessary for most, if not all, NMDAR-mediated excitotoxicity observed in rat brain slices and in vivo.<ref name="D-Serine_other_side"></ref> Pretreatment of rat hippocampal organotypic slices with D-serine deaminase was shown to practically abolish NMDA-mediated excitotoxicity, suggesting that D-serine, rather than glycine, participates in these excitotoxic events in the hippocampus.<ref name="D-Serine_other_side"></ref><br />
<br />
It is conceivable that '''D-serine''' signalling could be involved in brain disorders in which NMDARs contributes to the pathophysiology, such as stroke. Here, an indirect reduction of NMDAR-mediated excitotoxicity through modified D-serine supply may in principle suggest new therapeutic avenues. It is encouraging in that respect that SR deletion (i.e. serine racemase (SR), which converts L-serine to D-serine) was recently reported to reduce tissue damage in a mouse stroke model (Mustafa et al., 2010). However, increasing D-serine levels might on the other hand help to overcome cognitive impairments related to the dysfunction of NMDAR signaling. Promising early studies showed that '''Dcycloserine''', a partial agonist at the NMDAR co-agonist site, can improve spatial learning in rats (Monahan et al., 1989). Therapeutic approaches targeting D-serine signaling will therefore have to strike the balance between preventing NMDAR-dependent damage and avoiding cognitive impairment.<ref>D-Serine: A key to synaptic plasticity?,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375648/pdf/ukmss-48553.pdf</ref><br />
<br />
''Define: excitotoxicity:'' Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.<ref>Excitotoxicity,wikipedia,https://en.wikipedia.org/wiki/Excitotoxicity</ref><br />
<br />
== Oxidative Stress ==<br />
<br />
'''Oxidative stress theory for adult onset of psychosis:'''<br />
<br />
Oxidative stresses gradually increase until GSH (Glutathione) and MT (Metallothionein) proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT (neurotransmitter) levels, and disruption of the blood brain barrier. As in Wilson’s Disease, sudden onset of a mental illness in young adulthood may result.<ref name=walsh_imbalances>Biochemical imbalances in mental health populations, William J. Walsh PhD, Walsh Institute, http://www.walshinstitute.org/uploads/1/7/9/9/17997321/biochemical_imbalances_in_mental_health_populations.pdf</ref><br />
<br />
''Define: psychosis:'' a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.<ref>define: psychosis, Google, https://www.google.com/search?q=define%3Apsychosis</ref><br />
<br />
All major phenotypes of schizophrenia involve severe oxidative stress, [and] oxidative overload depletes GSH and reduces glutamate activity at NMDA receptors.<ref name="walsh_imbalances" /><br />
<br />
Abnormal methylation and severe oxidative stress are major causes of epigenetic errors, [and] greater than 95% of schizophrenics exhibit abnormal methylation or oxidative overload.<ref name="walsh_imbalances" /><br />
<br />
''Define: schizophrenia:'' a long-term mental disorder of a type involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, unfitting actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.<ref>define: schizophrenia, Google, https://www.google.com/search?q=define%3Aschizophrenia (edited)</ref><br />
<br />
== Other interesting links ==<br />
Schizophrenia, symptoms - https://www.sane.org/mental-health-and-illness/facts-and-guides/schizophrenia<br /><br />
OCD, Glycine - https://www.hindawi.com/archive/2014/859735/<br /><br />
Oxidation & it's results - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964749/#R37<br />
<br />
== '''Hypothesis''' ==<br />
* Increasing D-serine levels may help to overcome cognitive impairments related to the dysfunction of NMDAR signaling.<br />
* Increasing D-serine levels may cause NMDAR-dependent damage.<br />
* D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=D-Serine&diff=134
D-Serine
2017-04-28T05:54:03Z
<p>Roel Van de Paar: /* Other interesting links */</p>
<hr />
<div>== D-Serine and NMDA Receptors ==<br />
<br />
The NMDA (N-methyl-D-aspartate) receptor (also known as NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when '''glutamate''' and '''glycine (or D-serine)''' bind to it, and when activated it allows positively charged ions to flow through the cell membrane.<ref>''NMDA Receptor'', Wikipedia, https://en.wikipedia.org/wiki/NMDA_receptor</ref><br />
<br />
'''D-Serine''' supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced NMDA signaling, which includes cocaine dependence and schizophrenia.<ref>''D-Serine', Examine, https://examine.com/supplements/d-serine/</ref><br />
<br />
Treatment with '''D-serine''' can improve performance in tasks related to recognition learning and working memory, suggesting that this agent can be useful for the treatment of disorders involving declines in these cognitive domains. <ref>Effects of low-dose D-serine on recognition and working memory in mice,https://www.ncbi.nlm.nih.gov/pubmed/21556803</ref><br />
<br />
Because a <u>structural abnormality</u> and <u>NMDA receptor hypofunction</u> has been demonstrated in the cortex and hippocampus of schizophrenic subjects, D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<ref>Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat,https://www.ncbi.nlm.nih.gov/pubmed/15249164</ref><br />
<br />
''Define: hypofunction:'' Reduced, low, or inadequate function.<ref>Farlex Partner Medical Dictionary,© Farlex 2012</ref><br />
<br />
'''D-Serine''', synthesized in the brain by serine racemase from '''L-serine''' (its enantiomer), serves as a neuromodulator by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site of the NMDA-type glutamate receptor (NMDAR). For the receptor to open, glutamate and either glycine or D-serine must bind to it; in addition a pore blocker must not be bound (e.g. Mg2+ or Pb2+).[11] In fact, D-serine is a more potent agonist at the glycine site on the NMDAR than glycine itself.<ref>Serine,Wikipedia,https://en.wikipedia.org/wiki/Serine</ref><br />
<br />
''Define: agonist:'' (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.<ref>agonist,wiktionary,https://en.wiktionary.org/wiki/agonist</ref><br />
<br />
'''D-Serine''' is an <u>obligatory endogenous coagonist</u> of the NMDA receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine modulatory site.<ref>''D-Serine in Neuropsychiatric Disorders: New Advances'',Hindawi,https://www.hindawi.com/archive/2014/859735/</ref><br />
<br />
''Define: endogenous:'' (biology) growing or originating from within an organism.<ref>Define: endogenous,Google,https://www.google.com/search?q=define%3Aendogenous</ref><br /><br />
''Define: co-agonist:'' (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.<ref>co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist</ref><br /><br />
<br />
In addition to alleviating several diseases and conditions, '''D-serine''' may have its dark side in neurodegenerative disease.<ref name="D-Serine_other_side">D-serine as a gliotransmitter and its roles in brain development and disease,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632749/</ref> D-serine may play a role in excitotoxic neuronal death in Alzheimer’s disease and also in amyotrophic lateral sclerosis (ALS) as a principal cause for motoneuron death (considered to be excitotoxicity).<ref name="D-Serine_other_side"></ref> The presence of endogenous D-serine has been shown to be necessary for most, if not all, NMDAR-mediated excitotoxicity observed in rat brain slices and in vivo.<ref name="D-Serine_other_side"></ref> Pretreatment of rat hippocampal organotypic slices with D-serine deaminase was shown to practically abolish NMDA-mediated excitotoxicity, suggesting that D-serine, rather than glycine, participates in these excitotoxic events in the hippocampus.<ref name="D-Serine_other_side"></ref><br />
<br />
It is conceivable that '''D-serine''' signalling could be involved in brain disorders in which NMDARs contributes to the pathophysiology, such as stroke. Here, an indirect reduction of NMDAR-mediated excitotoxicity through modified D-serine supply may in principle suggest new therapeutic avenues. It is encouraging in that respect that SR deletion (i.e. serine racemase (SR), which converts L-serine to D-serine) was recently reported to reduce tissue damage in a mouse stroke model (Mustafa et al., 2010). However, increasing D-serine levels might on the other hand help to overcome cognitive impairments related to the dysfunction of NMDAR signaling. Promising early studies showed that '''Dcycloserine''', a partial agonist at the NMDAR co-agonist site, can improve spatial learning in rats (Monahan et al., 1989). Therapeutic approaches targeting D-serine signaling will therefore have to strike the balance between preventing NMDAR-dependent damage and avoiding cognitive impairment.<ref>D-Serine: A key to synaptic plasticity?,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375648/pdf/ukmss-48553.pdf</ref><br />
<br />
''Define: excitotoxicity:'' Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.<ref>Excitotoxicity,wikipedia,https://en.wikipedia.org/wiki/Excitotoxicity</ref><br />
<br />
== Oxidative Stress ==<br />
<br />
'''Oxidative stress theory for adult onset of psychosis:'''<br />
<br />
Oxidative stresses gradually increase until GSH (Glutathione) and MT (Metallothionein) proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT (neurotransmitter) levels, and disruption of the blood brain barrier. As in Wilson’s Disease, sudden onset of a mental illness in young adulthood may result.<ref name=walsh_imbalances>Biochemical imbalances in mental health populations, William J. Walsh PhD, Walsh Institute, http://www.walshinstitute.org/uploads/1/7/9/9/17997321/biochemical_imbalances_in_mental_health_populations.pdf</ref><br />
<br />
''Define: psychosis:'' a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.<ref>define: psychosis, Google, https://www.google.com/search?q=define%3Apsychosis</ref><br />
<br />
All major phenotypes of schizophrenia involve severe oxidative stress, [and] oxidative overload depletes GSH and reduces glutamate activity at NMDA receptors.<ref name="walsh_imbalances" /><br />
<br />
Abnormal methylation and severe oxidative stress are major causes of epigenetic errors, [and] greater than 95% of schizophrenics exhibit abnormal methylation or oxidative overload.<ref name="walsh_imbalances" /><br />
<br />
''Define: schizophrenia:'' a long-term mental disorder of a type involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, unfitting actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.<ref>define: schizophrenia, Google, https://www.google.com/search?q=define%3Aschizophrenia (edited)</ref><br />
<br />
== Other interesting links ==<br />
Schizophrenia, symptoms - https://www.sane.org/mental-health-and-illness/facts-and-guides/schizophrenia<br /><br />
OCD, Glycine - https://www.hindawi.com/archive/2014/859735/<br />
Oxidation & it's results - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964749/#R37<br />
<br />
== '''Hypothesis''' ==<br />
* Increasing D-serine levels may help to overcome cognitive impairments related to the dysfunction of NMDAR signaling.<br />
* Increasing D-serine levels may cause NMDAR-dependent damage.<br />
* D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=D-Serine&diff=133
D-Serine
2017-04-28T05:31:52Z
<p>Roel Van de Paar: /* D-Serine and NMDA Receptors */</p>
<hr />
<div>== D-Serine and NMDA Receptors ==<br />
<br />
The NMDA (N-methyl-D-aspartate) receptor (also known as NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when '''glutamate''' and '''glycine (or D-serine)''' bind to it, and when activated it allows positively charged ions to flow through the cell membrane.<ref>''NMDA Receptor'', Wikipedia, https://en.wikipedia.org/wiki/NMDA_receptor</ref><br />
<br />
'''D-Serine''' supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced NMDA signaling, which includes cocaine dependence and schizophrenia.<ref>''D-Serine', Examine, https://examine.com/supplements/d-serine/</ref><br />
<br />
Treatment with '''D-serine''' can improve performance in tasks related to recognition learning and working memory, suggesting that this agent can be useful for the treatment of disorders involving declines in these cognitive domains. <ref>Effects of low-dose D-serine on recognition and working memory in mice,https://www.ncbi.nlm.nih.gov/pubmed/21556803</ref><br />
<br />
Because a <u>structural abnormality</u> and <u>NMDA receptor hypofunction</u> has been demonstrated in the cortex and hippocampus of schizophrenic subjects, D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<ref>Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat,https://www.ncbi.nlm.nih.gov/pubmed/15249164</ref><br />
<br />
''Define: hypofunction:'' Reduced, low, or inadequate function.<ref>Farlex Partner Medical Dictionary,© Farlex 2012</ref><br />
<br />
'''D-Serine''', synthesized in the brain by serine racemase from '''L-serine''' (its enantiomer), serves as a neuromodulator by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site of the NMDA-type glutamate receptor (NMDAR). For the receptor to open, glutamate and either glycine or D-serine must bind to it; in addition a pore blocker must not be bound (e.g. Mg2+ or Pb2+).[11] In fact, D-serine is a more potent agonist at the glycine site on the NMDAR than glycine itself.<ref>Serine,Wikipedia,https://en.wikipedia.org/wiki/Serine</ref><br />
<br />
''Define: agonist:'' (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.<ref>agonist,wiktionary,https://en.wiktionary.org/wiki/agonist</ref><br />
<br />
'''D-Serine''' is an <u>obligatory endogenous coagonist</u> of the NMDA receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine modulatory site.<ref>''D-Serine in Neuropsychiatric Disorders: New Advances'',Hindawi,https://www.hindawi.com/archive/2014/859735/</ref><br />
<br />
''Define: endogenous:'' (biology) growing or originating from within an organism.<ref>Define: endogenous,Google,https://www.google.com/search?q=define%3Aendogenous</ref><br /><br />
''Define: co-agonist:'' (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.<ref>co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist</ref><br /><br />
<br />
In addition to alleviating several diseases and conditions, '''D-serine''' may have its dark side in neurodegenerative disease.<ref name="D-Serine_other_side">D-serine as a gliotransmitter and its roles in brain development and disease,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632749/</ref> D-serine may play a role in excitotoxic neuronal death in Alzheimer’s disease and also in amyotrophic lateral sclerosis (ALS) as a principal cause for motoneuron death (considered to be excitotoxicity).<ref name="D-Serine_other_side"></ref> The presence of endogenous D-serine has been shown to be necessary for most, if not all, NMDAR-mediated excitotoxicity observed in rat brain slices and in vivo.<ref name="D-Serine_other_side"></ref> Pretreatment of rat hippocampal organotypic slices with D-serine deaminase was shown to practically abolish NMDA-mediated excitotoxicity, suggesting that D-serine, rather than glycine, participates in these excitotoxic events in the hippocampus.<ref name="D-Serine_other_side"></ref><br />
<br />
It is conceivable that '''D-serine''' signalling could be involved in brain disorders in which NMDARs contributes to the pathophysiology, such as stroke. Here, an indirect reduction of NMDAR-mediated excitotoxicity through modified D-serine supply may in principle suggest new therapeutic avenues. It is encouraging in that respect that SR deletion (i.e. serine racemase (SR), which converts L-serine to D-serine) was recently reported to reduce tissue damage in a mouse stroke model (Mustafa et al., 2010). However, increasing D-serine levels might on the other hand help to overcome cognitive impairments related to the dysfunction of NMDAR signaling. Promising early studies showed that '''Dcycloserine''', a partial agonist at the NMDAR co-agonist site, can improve spatial learning in rats (Monahan et al., 1989). Therapeutic approaches targeting D-serine signaling will therefore have to strike the balance between preventing NMDAR-dependent damage and avoiding cognitive impairment.<ref>D-Serine: A key to synaptic plasticity?,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375648/pdf/ukmss-48553.pdf</ref><br />
<br />
''Define: excitotoxicity:'' Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.<ref>Excitotoxicity,wikipedia,https://en.wikipedia.org/wiki/Excitotoxicity</ref><br />
<br />
== Oxidative Stress ==<br />
<br />
'''Oxidative stress theory for adult onset of psychosis:'''<br />
<br />
Oxidative stresses gradually increase until GSH (Glutathione) and MT (Metallothionein) proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT (neurotransmitter) levels, and disruption of the blood brain barrier. As in Wilson’s Disease, sudden onset of a mental illness in young adulthood may result.<ref name=walsh_imbalances>Biochemical imbalances in mental health populations, William J. Walsh PhD, Walsh Institute, http://www.walshinstitute.org/uploads/1/7/9/9/17997321/biochemical_imbalances_in_mental_health_populations.pdf</ref><br />
<br />
''Define: psychosis:'' a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.<ref>define: psychosis, Google, https://www.google.com/search?q=define%3Apsychosis</ref><br />
<br />
All major phenotypes of schizophrenia involve severe oxidative stress, [and] oxidative overload depletes GSH and reduces glutamate activity at NMDA receptors.<ref name="walsh_imbalances" /><br />
<br />
Abnormal methylation and severe oxidative stress are major causes of epigenetic errors, [and] greater than 95% of schizophrenics exhibit abnormal methylation or oxidative overload.<ref name="walsh_imbalances" /><br />
<br />
''Define: schizophrenia:'' a long-term mental disorder of a type involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, unfitting actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.<ref>define: schizophrenia, Google, https://www.google.com/search?q=define%3Aschizophrenia (edited)</ref><br />
<br />
== Other interesting links ==<br />
Schizophrenia, symptoms - https://www.sane.org/mental-health-and-illness/facts-and-guides/schizophrenia<br /><br />
OCD, Glycine - https://www.hindawi.com/archive/2014/859735/<br />
<br />
== '''Hypothesis''' ==<br />
* Increasing D-serine levels may help to overcome cognitive impairments related to the dysfunction of NMDAR signaling.<br />
* Increasing D-serine levels may cause NMDAR-dependent damage.<br />
* D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=D-Serine&diff=132
D-Serine
2017-04-28T05:30:35Z
<p>Roel Van de Paar: </p>
<hr />
<div>== D-Serine and NMDA Receptors ==<br />
<br />
The NMDA (N-methyl-D-aspartate) receptor (also known as NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when '''glutamate''' and '''glycine (or D-serine)''' bind to it, and when activated it allows positively charged ions to flow through the cell membrane.<ref>''NMDA Receptor'', Wikipedia, https://en.wikipedia.org/wiki/NMDA_receptor</ref><br />
<br />
'''D-Serine''' supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced NMDA signaling, which includes cocaine dependence and schizophrenia.<ref>''D-Serine', Examine, https://examine.com/supplements/d-serine/</ref><br />
<br />
Treatment with '''D-serine''' can improve performance in tasks related to recognition learning and working memory, suggesting that this agent can be useful for the treatment of disorders involving declines in these cognitive domains. <ref>Effects of low-dose D-serine on recognition and working memory in mice,https://www.ncbi.nlm.nih.gov/pubmed/21556803</ref><br />
<br />
Because a <u>structural abnormality</u> and <u>NMDA receptor hypofunction</u> has been demonstrated in the cortex and hippocampus of schizophrenic subjects, D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<ref>Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat,https://www.ncbi.nlm.nih.gov/pubmed/15249164</ref><br />
<br />
''Define: hypofunction:'' Reduced, low, or inadequate function.<ref>Farlex Partner Medical Dictionary,© Farlex 2012</ref><br />
<br />
'''D-Serine''' is an <u>obligatory endogenous coagonist</u> of the NMDA receptor, functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine modulatory site.<ref>''D-Serine in Neuropsychiatric Disorders: New Advances'',Hindawi,https://www.hindawi.com/archive/2014/859735/</ref><br />
<br />
''Define: endogenous:'' (biology) growing or originating from within an organism.<ref>Define: endogenous,Google,https://www.google.com/search?q=define%3Aendogenous</ref><br /><br />
''Define: co-agonist:'' (biochemistry) A drug or other chemical that can combine with a receptor on a cell to produce a physiologic reaction typical of a naturally occurring substance. Co-agonist implies it is one of other agonists working in conjunction.<ref>co-agonist,wiktionary,https://en.wiktionary.org/wiki/co-agonist</ref><br /><br />
''Define: agonist:'' (biochemistry) A molecule that can combine with a receptor on a cell to produce a physiological reaction.<ref>agonist,wiktionary,https://en.wiktionary.org/wiki/agonist</ref><br />
<br />
In addition to alleviating several diseases and conditions, '''D-serine''' may have its dark side in neurodegenerative disease.<ref name="D-Serine_other_side">D-serine as a gliotransmitter and its roles in brain development and disease,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632749/</ref> D-serine may play a role in excitotoxic neuronal death in Alzheimer’s disease and also in amyotrophic lateral sclerosis (ALS) as a principal cause for motoneuron death (considered to be excitotoxicity).<ref name="D-Serine_other_side"></ref> The presence of endogenous D-serine has been shown to be necessary for most, if not all, NMDAR-mediated excitotoxicity observed in rat brain slices and in vivo.<ref name="D-Serine_other_side"></ref> Pretreatment of rat hippocampal organotypic slices with D-serine deaminase was shown to practically abolish NMDA-mediated excitotoxicity, suggesting that D-serine, rather than glycine, participates in these excitotoxic events in the hippocampus.<ref name="D-Serine_other_side"></ref><br />
<br />
It is conceivable that '''D-serine''' signalling could be involved in brain disorders in which NMDARs contributes to the pathophysiology, such as stroke. Here, an indirect reduction of NMDAR-mediated excitotoxicity through modified D-serine supply may in principle suggest new therapeutic avenues. It is encouraging in that respect that SR deletion (i.e. serine racemase (SR), which converts L-serine to D-serine) was recently reported to reduce tissue damage in a mouse stroke model (Mustafa et al., 2010). However, increasing D-serine levels might on the other hand help to overcome cognitive impairments related to the dysfunction of NMDAR signaling. Promising early studies showed that '''Dcycloserine''', a partial agonist at the NMDAR co-agonist site, can improve spatial learning in rats (Monahan et al., 1989). Therapeutic approaches targeting D-serine signaling will therefore have to strike the balance between preventing NMDAR-dependent damage and avoiding cognitive impairment.<ref>D-Serine: A key to synaptic plasticity?,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375648/pdf/ukmss-48553.pdf</ref><br />
<br />
''Define: excitotoxicity:'' Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.<ref>Excitotoxicity,wikipedia,https://en.wikipedia.org/wiki/Excitotoxicity</ref><br />
<br />
D-Serine, synthesized in the brain by serine racemase from L-serine (its enantiomer), serves as a neuromodulator by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site of the NMDA-type glutamate receptor (NMDAR). For the receptor to open, glutamate and either glycine or D-serine must bind to it; in addition a pore blocker must not be bound (e.g. Mg2+ or Pb2+).[11] In fact, D-serine is a more potent agonist at the glycine site on the NMDAR than glycine itself.<ref>Serine,Wikipedia,https://en.wikipedia.org/wiki/Serine</ref><br />
<br />
== Oxidative Stress ==<br />
<br />
'''Oxidative stress theory for adult onset of psychosis:'''<br />
<br />
Oxidative stresses gradually increase until GSH (Glutathione) and MT (Metallothionein) proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT (neurotransmitter) levels, and disruption of the blood brain barrier. As in Wilson’s Disease, sudden onset of a mental illness in young adulthood may result.<ref name=walsh_imbalances>Biochemical imbalances in mental health populations, William J. Walsh PhD, Walsh Institute, http://www.walshinstitute.org/uploads/1/7/9/9/17997321/biochemical_imbalances_in_mental_health_populations.pdf</ref><br />
<br />
''Define: psychosis:'' a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.<ref>define: psychosis, Google, https://www.google.com/search?q=define%3Apsychosis</ref><br />
<br />
All major phenotypes of schizophrenia involve severe oxidative stress, [and] oxidative overload depletes GSH and reduces glutamate activity at NMDA receptors.<ref name="walsh_imbalances" /><br />
<br />
Abnormal methylation and severe oxidative stress are major causes of epigenetic errors, [and] greater than 95% of schizophrenics exhibit abnormal methylation or oxidative overload.<ref name="walsh_imbalances" /><br />
<br />
''Define: schizophrenia:'' a long-term mental disorder of a type involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, unfitting actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.<ref>define: schizophrenia, Google, https://www.google.com/search?q=define%3Aschizophrenia (edited)</ref><br />
<br />
== Other interesting links ==<br />
Schizophrenia, symptoms - https://www.sane.org/mental-health-and-illness/facts-and-guides/schizophrenia<br /><br />
OCD, Glycine - https://www.hindawi.com/archive/2014/859735/<br />
<br />
== '''Hypothesis''' ==<br />
* Increasing D-serine levels may help to overcome cognitive impairments related to the dysfunction of NMDAR signaling.<br />
* Increasing D-serine levels may cause NMDAR-dependent damage.<br />
* D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Creatine&diff=131
Creatine
2017-04-28T05:10:44Z
<p>Roel Van de Paar: </p>
<hr />
<div>* Creatine appears to be neuroprotective against glutamate-induced excitotoxicity.<ref name="creatineexamine">Creatine,Examine,https://examine.com/supplements/creatine/</ref><br />
<br />
* Glutamate-induced excitotoxicity is caused by excessive intracellular calcium levels resulting from ATP (adenosine triphosphate) depletion.<ref name="creatineexamine"></ref><br />
<br />
* <br />
<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Creatine&diff=130
Creatine
2017-04-28T05:09:01Z
<p>Roel Van de Paar: Created page with "* Creatine appears to be neuroprotective against glutamate-induced excitotoxicity.<ref name="creatineexamine">Creatine,Examine,https://examine.com/supplements/creatine/</ref>..."</p>
<hr />
<div>* Creatine appears to be neuroprotective against glutamate-induced excitotoxicity.<ref name="creatineexamine">Creatine,Examine,https://examine.com/supplements/creatine/</ref><br />
<br />
* Glutamate-induced excitotoxicity is caused by excessive intracellular calcium levels resulting from ATP depletion.<ref name="creatineexamine"></ref><br />
<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=129
Main Page
2017-04-28T05:08:37Z
<p>Roel Van de Paar: Removed protection from "Main Page"</p>
<hr />
<div>'''Welcome to Practical Healing!'''<br />
<br />
''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."'' -- Jesus<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Get blood and urine tests done as prescribed by your GP. Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
** <info to add: copper tests etc.><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft supplement pages;<br />
* [[D-Serine]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin C]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=128
Main Page
2017-04-28T05:08:01Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''Welcome to Practical Healing!'''<br />
<br />
''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."'' -- Jesus<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Get blood and urine tests done as prescribed by your GP. Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
** <info to add: copper tests etc.><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft supplement pages;<br />
* [[D-Serine]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin C]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
* [[Creatine]]<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Practical_Healing:About&diff=127
Practical Healing:About
2017-04-25T21:46:03Z
<p>Roel Van de Paar: </p>
<hr />
<div>Practical Healing is a website to help you heal your health and more in a practical manner.<br />
<br />
This website is composed with the help of many people, and it's contents are for research only. You should do your own research and not implement any information from this website into practice without first speaking with a licensed doctor and a licensed naturopath.<br />
<br />
Please also see [[Practical_Healing:General_disclaimer]]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Practical_Healing:About&diff=126
Practical Healing:About
2017-04-25T21:45:54Z
<p>Roel Van de Paar: </p>
<hr />
<div>Practical Healing is a website to help you heal your health and more in a practical manner.<br />
<br />
This website is composed with the help of many people, and it's contents are for research only. You should do your own research and not implement any information from this website into practice without first speaking with a licensed doctor and a licensed naturopath.<br />
<br />
Please also see [[Disclaimers Practical_Healing:General_disclaimer]]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Practical_Healing:About&diff=125
Practical Healing:About
2017-04-25T21:45:41Z
<p>Roel Van de Paar: </p>
<hr />
<div>Practical Healing is a website to help you heal your health and more in a practical manner.<br />
<br />
This website is composed with the help of many people, and it's contents are for research only. You should do your own research and not implement any information from this website into practice without first speaking with a licensed doctor and a licensed naturopath.<br />
<br />
Please also see [[Practical_Healing:General_disclaimer Disclaimers]]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Practical_Healing:About&diff=124
Practical Healing:About
2017-04-25T21:45:08Z
<p>Roel Van de Paar: </p>
<hr />
<div>Practical Healing is a website to help you heal your health and more in a practical manner.<br />
<br />
This website is composed with the help of many people, and it's contents are for research only. You should do your own research and not implement any information from this website into practice without first speaking with a licensed doctor and a licensed naturopath.<br />
<br />
Please also see [[Practical_Healing:General_disclaimer]]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Practical_Healing:General_disclaimer&diff=123
Practical Healing:General disclaimer
2017-04-25T21:43:58Z
<p>Roel Van de Paar: </p>
<hr />
<div>- This website is composed with the help of many people, including people who are not medically trained, and it's contents are FOR RESEARCH ONLY. You must do your own research and not implement any information from this website into practice without first speaking with a licensed doctor and a licensed naturopath.<br />
<br />
- You warrant that any content you submit to this website is free from any copyright and any other encumberment. You warrant that you are legally allowed to submit such content. You warrant that any content you submit becomes - at the moment of submission - the sole property of practicalhealing.com <br />
<br />
- You understand that any input/editing you provide may be edited again by other users or practicalhealing.com moderators. In some case, for example spam, practicalhealing.com moderators may even remove your input/edits entirely. In extreme cases of misuse, practicalhealing.com moderators may block your account.<br />
<br />
- This website links to many websites on the net. Some are highly moral, others less so. Such sites are not under our control and they may contain information we do not agree with. It is also suggested to use advertising, image, and script blockers when visiting various sites around the net. Some suggestions are AdBlockPlus, NoScript, Image block etc.</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Potassium&diff=122
Potassium
2017-04-25T21:21:42Z
<p>Roel Van de Paar: /* Symptoms of deficiency */</p>
<hr />
<div>== Potassium ==<br />
<br />
* Potassium protects against stroke<ref>Potassium,Examine,https://examine.com/supplements/potassium/</ref><br />
<br />
<br />
== Symptoms of deficiency == <br />
<br />
Note; Symptoms may be vague or mild and involve the muscles, heart, nerves and gastrointestinal (GI) tract.<ref name="boots">Low Potassium Hypokalaemia,webmd.boots.com,http://www.webmd.boots.com/a-to-z-guides/low-potassium-hypokalaemia</ref><br />
<br />
Symptoms;<ref name="boots"></ref><ref>Low Potassium Linked To High Blood Pressure,ScienceDaily,https://www.sciencedaily.com/releases/2008/11/081109074611.htm</ref><ref>Low Potassium Hypokalemia,Medicinenet,http://www.medicinenet.com/low_potassium_hypokalemia/page2.htm</ref><ref>Low Potassium,Dr. Axe,https://draxe.com/low-potassium/</ref><br />
* High blood pressure<br />
* Weakness, aches, tiredness, or cramping in arm or leg muscles, sometimes alike to paralysis<br />
* Tingling or numbness<br />
* Nausea or vomiting<br />
* Abdominal cramping, bloating<br />
* Constipation<br />
* Palpitations (irregular heartbeat) <br />
* Passing large amounts of urine or feeling very thirsty most of the time<br />
* Fainting due to low blood pressure<br />
* Depression, psychosis, delirium, confusion or hallucinations<br />
* Fatigue and trouble getting a good sleep<br />
* Poor concentration and memory<br />
<br />
== Opinions ==<br />
* Symptoms of need for Potassium? High blood pressure, heart palpitations, fatigue, etc.. listen to your body. If your not getting potassium in your diet then symptoms should be easy to spot.<ref>Katie Gironda,Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Potassium&diff=121
Potassium
2017-04-25T21:19:16Z
<p>Roel Van de Paar: /* Symptoms of deficiency */</p>
<hr />
<div>== Potassium ==<br />
<br />
* Potassium protects against stroke<ref>Potassium,Examine,https://examine.com/supplements/potassium/</ref><br />
<br />
<br />
== Symptoms of deficiency == <br />
<br />
Note; Symptoms may be vague or mild and involve the muscles, heart, nerves and gastrointestinal (GI) tract.<ref name="boots">Low Potassium Hypokalaemia,webmd.boots.com,http://www.webmd.boots.com/a-to-z-guides/low-potassium-hypokalaemia</ref><br />
<br />
Specific symptoms;<ref name="boots"></ref><ref>Low Potassium Linked To High Blood Pressure,ScienceDaily,https://www.sciencedaily.com/releases/2008/11/081109074611.htm</ref><ref>Low Potassium Hypokalemia,Medicinenet,http://www.medicinenet.com/low_potassium_hypokalemia/page2.htm</ref><br />
* High blood pressure<br />
* Weakness, aches, tiredness, or cramping in arm or leg muscles, sometimes alike to paralysis<br />
* Tingling or numbness<br />
* Nausea or vomiting<br />
* Abdominal cramping, bloating<br />
* Constipation<br />
* Palpitations (irregular heartbeat) <br />
* Passing large amounts of urine or feeling very thirsty most of the time<br />
* Fainting due to low blood pressure<br />
* Depression, psychosis, delirium, confusion or hallucinations<br />
<br />
== Opinions ==<br />
* Symptoms of need for Potassium? High blood pressure, heart palpitations, fatigue, etc.. listen to your body. If your not getting potassium in your diet then symptoms should be easy to spot.<ref>Katie Gironda,Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Potassium&diff=120
Potassium
2017-04-25T21:18:58Z
<p>Roel Van de Paar: </p>
<hr />
<div>== Potassium ==<br />
<br />
* Potassium protects against stroke<ref>Potassium,Examine,https://examine.com/supplements/potassium/</ref><br />
<br />
<br />
== Symptoms of deficiency == <br />
<br />
Note; Symptoms may be vague or mild and involve the muscles, heart, nerves and gastrointestinal (GI) tract.<ref name="boots">Low Potassium Hypokalaemia,webmd.boots.com,http://www.webmd.boots.com/a-to-z-guides/low-potassium-hypokalaemia</ref><br />
<br />
Specific symptoms;<ref>Low Potassium Linked To High Blood Pressure,ScienceDaily,https://www.sciencedaily.com/releases/2008/11/081109074611.htm</ref><ref name="boots"></ref><ref>Low Potassium Hypokalemia,Medicinenet,http://www.medicinenet.com/low_potassium_hypokalemia/page2.htm</ref><br />
* High blood pressure<br />
* Weakness, aches, tiredness, or cramping in arm or leg muscles, sometimes alike to paralysis<br />
* Tingling or numbness<br />
* Nausea or vomiting<br />
* Abdominal cramping, bloating<br />
* Constipation<br />
* Palpitations (irregular heartbeat) <br />
* Passing large amounts of urine or feeling very thirsty most of the time<br />
* Fainting due to low blood pressure<br />
* Depression, psychosis, delirium, confusion or hallucinations<br />
<br />
== Opinions ==<br />
* Symptoms of need for Potassium? High blood pressure, heart palpitations, fatigue, etc.. listen to your body. If your not getting potassium in your diet then symptoms should be easy to spot.<ref>Katie Gironda,Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Potassium&diff=119
Potassium
2017-04-25T21:15:23Z
<p>Roel Van de Paar: </p>
<hr />
<div>== Potassium ==<br />
<br />
* Potassium protects against stroke<ref>Potassium,Examine,https://examine.com/supplements/potassium/</ref><br />
<br />
<br />
== Symptoms of deficiency == <br />
<br />
Note; Symptoms may be vague or mild and involve the muscles, heart, nerves and gastrointestinal (GI) tract.<ref name="boots">Low Potassium Hypokalaemia,webmd.boots.com,http://www.webmd.boots.com/a-to-z-guides/low-potassium-hypokalaemia</ref><br />
<br />
Specific symptoms;<ref name="boots"></ref><br />
* Weakness, tiredness, or cramping in arm or leg muscles, sometimes alike to paralysis<br />
* Tingling or numbness<br />
* Nausea or vomiting<br />
* Abdominal cramping, bloating<br />
* Constipation<br />
* Palpitations (irregular heartbeat) <br />
* Passing large amounts of urine or feeling very thirsty most of the time<br />
* Fainting due to low blood pressure<br />
* Depression, psychosis, delirium, confusion or hallucinations.<br />
<br />
== Opinions ==<br />
* Symptoms of need for Potassium? High blood pressure, heart palpitations, fatigue, etc.. listen to your body. If your not getting potassium in your diet then symptoms should be easy to spot.<ref>Katie Gironda,Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Potassium&diff=118
Potassium
2017-04-25T21:14:46Z
<p>Roel Van de Paar: </p>
<hr />
<div>== Potassium ==<br />
<br />
* Potassium protects against stroke<ref>Potassium,Examine,https://examine.com/supplements/potassium/</ref><br />
<br />
<br />
== Symptoms of deficiency == <br />
<br />
Note; Symptoms may be vague or mild and involve the muscles, heart, nerves and gastrointestinal (GI) tract.<ref name="boots">Low Potassium Hypokalaemia,webmd.boots.com,http://www.webmd.boots.com/a-to-z-guides/low-potassium-hypokalaemia</ref><br />
<br />
* Weakness, tiredness, or cramping in arm or leg muscles, sometimes alike to paralysis<br />
* Tingling or numbness<br />
* Nausea or vomiting<br />
* Abdominal cramping, bloating<br />
* Constipation<br />
* Palpitations (irregular heartbeat) <br />
* Passing large amounts of urine or feeling very thirsty most of the time<br />
* Fainting due to low blood pressure<br />
* Depression, psychosis, delirium, confusion or hallucinations.<ref name="boots"></ref><br />
<br />
== Opinions ==<br />
* Symptoms of need for Potassium? High blood pressure, heart palpitations, fatigue, etc.. listen to your body. If your not getting potassium in your diet then symptoms should be easy to spot.<ref>Katie Gironda,Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Potassium&diff=117
Potassium
2017-04-25T21:14:29Z
<p>Roel Van de Paar: </p>
<hr />
<div>== Potassium ==<br />
<br />
* Potassium protects against stroke<ref>Potassium,Examine,https://examine.com/supplements/potassium/</ref><br />
<br />
<br />
== Symptoms of deficiency == <br />
<br />
Note; Symptoms may be vague or mild and involve the muscles, heart, nerves and gastrointestinal (GI) tract.<ref title="boots">Low Potassium Hypokalaemia,webmd.boots.com,http://www.webmd.boots.com/a-to-z-guides/low-potassium-hypokalaemia</ref><br />
<br />
* Weakness, tiredness, or cramping in arm or leg muscles, sometimes alike to paralysis<br />
* Tingling or numbness<br />
* Nausea or vomiting<br />
* Abdominal cramping, bloating<br />
* Constipation<br />
* Palpitations (irregular heartbeat) <br />
* Passing large amounts of urine or feeling very thirsty most of the time<br />
* Fainting due to low blood pressure<br />
* Depression, psychosis, delirium, confusion or hallucinations.<ref title="boots"></ref><br />
<br />
== Opinions ==<br />
* Symptoms of need for Potassium? High blood pressure, heart palpitations, fatigue, etc.. listen to your body. If your not getting potassium in your diet then symptoms should be easy to spot.<ref>Katie Gironda,Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Vitamin_C&diff=116
Vitamin C
2017-04-25T20:49:32Z
<p>Roel Van de Paar: </p>
<hr />
<div>== Vitamin C & Liposomal Vitamin C ==<br />
<br />
<br />
== Opinions ==<br />
* Cancer devours the bodies vitamin c. Also other nutrients. Someone with leukemia really needs vitamin c.<ref name="vitcfb">Katie Gironda,Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
* Other options; sodium ascorbate (but note the salt content!) or pure powder ascorbic acid and put a little baking soda in<ref name="vitcfb"></ref><br />
<br />
== Cautions ==<br />
* Pregnant women are not advised to take Liposomal Vitamin c. ["]We["] [Katie Gironda?] have reason to believe phosphatidylcholine breaks down trophoblasts.<ref name="vitcfb"></ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Potassium&diff=115
Potassium
2017-04-25T20:47:29Z
<p>Roel Van de Paar: </p>
<hr />
<div>== Potassium ==<br />
<br />
* Potassium protects against stroke<ref>Potassium,Examine,https://examine.com/supplements/potassium/</ref><br />
<br />
<br />
== Opinions ==<br />
* Symptoms of need for Potassium? High blood pressure, heart palpitations, fatigue, etc.. listen to your body. If your not getting potassium in your diet then symptoms should be easy to spot.<ref>Katie Gironda,Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Vitamin_C&diff=114
Vitamin C
2017-04-25T20:38:59Z
<p>Roel Van de Paar: </p>
<hr />
<div>== Vitamin C & Liposomal Vitamin C ==<br />
<br />
<br />
== Opinions ==<br />
* Cancer devours the bodies vitamin c. Also other nutrients. Someone with leukemia really needs vitamin c.<ref>Katie Gironda,Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
<br />
== Cautions ==<br />
* Pregnant women are not advised to take Liposomal Vitamin c. ["]We["] [Katie Gironda?] have reason to believe phosphatidylcholine breaks down trophoblasts.<ref>Vitamin C for optimal health,Facebook group,https://www.facebook.com/groups/VitaminCforoptimalhealth/permalink/1780259525525795/</ref><br />
<br />
<br />
== References ==<br />
<references /></div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Main_Page&diff=113
Main Page
2017-04-25T04:35:22Z
<p>Roel Van de Paar: </p>
<hr />
<div>'''Welcome to Practical Healing!'''<br />
<br />
''"Peace I leave you; My Peace I give to you. Not as the world gives do I give to you. Do not let your hearts be troubled or afraid."'' -- Jesus<br />
<br />
This website will help you, in a practical way, on your path to healing. <br />
<br />
You are free to contribute along the way, and edit this website as you see fit. Please accept that your input may be edited further by us or other users.<br />
<br />
Please make sure to read our disclaimers (see footnote 'Disclaimers' link) first.<br />
<br />
To get started on your journey of healing, take these steps;<br /><br />
* Find a GP or Naturopath which has been trained in the work of Dr. Walsh and Dr. Pfeiffer<br />
** US: http://www.walshinstitute.org/clinical-resources.html<br />
** AU: http://www.biobalance.org.au/patients/find-practitioners<br />
* Get blood and urine tests done as prescribed by your GP. Ask to include at least the following;<br />
** Urinary Pyrrole (Other names; Mauve Factor, uHPL, Kryptopyrrole test)<br />
*** US: <info to add><br />
*** AU: strong recommendation to use <u>Applied Analytical Laboratories Pty Ltd</u> and would caution against using SAFE Analytical Laboratories<br />
**** The staff at Applied Analytical Laboratories are very friendly, efficient/fast, and the reports are clear and detailed<br />
** <info to add: copper tests etc.><br />
* Make a baseline "how I feel" chart, with at least 6 indicators, preferably before starting any supplements or treatment<br />
** For example, include "mental", "physical", "energy", "spiritually", "connection with others", "at work", "feeling", "sickness"<br />
*** There is no new age thinking here; "energy" simply refers to how energised you felt during the day, etc. <br />
** Also include some symptom specific items as they relate to you, for example "anxiety", "frustration", "anger", "hyper activity", etc.<br />
** Spent some time evaluating the last 6-12 months of your life and choose the indicators as specifically and perhaps semi-broadly as possible. This will help later<br />
** Rate each of them on a scale from 0-100, or use 0-5 if 0-100 is too detailed for you. This will help track progress later<br />
* Pray and ask God for help. He will help you. Many can attest of this<br />
<br />
Draft supplement pages;<br />
* [[D-Serine]]<br />
* [[Vitamin B3]]<br />
* [[Vitamin C]]<br />
* [[Vitamin B5]]<br />
* [[Vitamin B12]]<br />
* [[Calcium]] (includes information about Vitamins D and K2)<br />
* [[Potassium]]<br />
<br />
Draft topic pages;<br />
* [[Cardiovascular]]<br />
<br />
We also setup our blog now at [http://practicalhealing.com/blog Practical Healing Blog]</div>
Roel Van de Paar
http://practicalhealing.com/index.php?title=Talk:Vitamin_C&diff=112
Talk:Vitamin C
2017-04-24T22:49:49Z
<p>Roel Van de Paar: Created page with "* In time, may have to split Vitamin C from Liposomal Vitamin C page"</p>
<hr />
<div>* In time, may have to split Vitamin C from Liposomal Vitamin C page</div>
Roel Van de Paar